The FitzDeanes are wealthy. They have Ballyford Castle in Ireland and a growing shipping business in Liverpool, but a previous generation made a terrible mistake and now there are whispers that the family is cursed, unable to produce a living heir.

When young Ruby Flynn arrives to work at Ballyford, rumours start swirling around this beautiful girl with a mysterious past. Who is she really? And what will her arrival mean for this powerful family divided by tragedy?

It is 1953, and five girls are arriving to start their training at St Angelus Hospital. Dana has escaped from her family farm in Ireland. Victoria is running away from an aristocratic background. Beth is an army brat and throws her lot in with bitchy Celia Forsyth, and Pammy has come from the wrong side of the tracks. When an unknown girl is admitted after a botched backstreet abortion, a tragedy begins to unfold which will rock the world of St Angelus to its foundations.

1950s Liverpool. In the tight-knit community of the Four Streets, two girls are growing up. One is motherless and hated by the cold woman determined to take her dead mother's place. The other is hiding a dreadful secret which she dare not tell to anyone. The people of Four Streets laugh, grieve and hope together. But what can they do when a betrayal at the heart of their world comes to light?

Christmas is one of the most harrowing times of year for the nurses of St Angelus Hospital.  The Matron takes on Tilly, a new clerk, to ease the load in the busy festive period. Tilly is bright and hardworking, but she is keeping a secret from her colleagues. Everyday Tilly makes a heartbreaking decision - but she has no other choice. If Matron - with her traditional values and strict discipline -learnt the truth about her new clerk, Tilly's career would be ruined. Could Matron ever forgive the deceit?

Maureen Jackson is a prisoner of her father's blackmail. Three years ago, she'd been hoping to marry Rory, the man of her dreams. However, after her mother's death, Maureen was left to care for her overbearing father. Now Rory is back in London with his pregnant wife and reminds Maureen of the life that should have been hers. With the war looming, Janet Ashley hopes to marry her sweetheart Mike, but her father refuses to grant them his blessing. Janet finds herself pregnant and her mother Peggy is determined to hold her family together.

After the heartbreak of World War Two, newlywed midwife Cathy hoped Liverpool life would offer some joy. But a terrible miscarriage and the escape of her abusive stepfather Jack from prison make happiness hard to find. Meanwhile, Cathy’s beloved granny is ailing. Whilst at the hospital, Cathy sees her midwifery friends, who are planning to open a home for unmarried mothers. After losing a baby of her own, Cathy would love to help, but for now, she must take care of her grandmother.  

At the heart of Dover's Market Square lies the Castle's Café. A bustling, homely place run by the formidable Nellie Castle and her six children. Since the scandalous birth of her beloved son 10 years before, Marianne, Nellie's eldest daughter, has preferred to stay in the kitchen, hidden away from the town gossips. Overcome with shame, Marianne has never revealed the name of Donny's father - not even to her own mother. But with World War II just around the corner, Marianne's past catches up with her. And suddenly the lives of the Castle family become a lot more complicated.

Bristol, 1939. School leaver Maisie Miles suspects her father, a small-time crook, has an ulterior motive for insisting she gets a job at the W. D. & H. O. Wills tobacco factory but keeps it to herself. She's befriended by effervescent Phyllis Mason and kind-hearted Bridget Milligan who take pity on her and take Maisie under their wing. But beneath their happy-go-lucky exteriors, they all harbour dreams and worries about what the future holds. 

1943, Hampshire. Pixie Saunders is 19 and employed in the local armaments factory. Not for the first time, her mother has run off with a dodgy-looking bloke, leaving Pixie to pay the rent and fend for herself. Pixie, along with her best friend, Rita; Em, the factory overseer; and the rest of the girls are making the most of the war while trying to stay alive. The work is dangerous and the hours long, but in the evenings they take off their overalls and go to the pub or, better still, go dancing.

Hattie finds herself relegated to the factory floor on her return from the war. Her workmates are unforgiving at Hattie's attempt to raise herself up, and she is soon ostracised. After journeying to Australia to marry her husband, Clara is betrayed and returns penniless, homeless and trying to raise a child alone. Lou's daughter and parents are killed by a bomb blast. By day she works at the factory; by night she roams the bomb sites, half mad with grief. These women forge a bond that will ultimately allow them to find hope.

1940, Liverpool: Alice Turner and her best friend, Millie Markham, work for the war effort at Rootes munitions factory, making shell caps and Halifax bombers. Alice’s sweetheart, Terry, is home from the front for a brief period of leave. But the honeymoon is soon over. Terry must go back to the dangers of Nazi-occupied France, and the ever-present air raid sirens quickly bring Alice back down to earth. 

1850. When Opal Sharp finds herself and her younger siblings suddenly orphaned and destitute, she thinks things can get no worse. But soon three of them - including Opal - are struck down with the illness that took their father from them, and her brother Charlie is forced to make an impossible decision. Unable to afford a doctor, he knows the younger children will not survive. So, unbeknownst to Opal, Charlie takes their younger siblings to the workhouse, where he knows they will at least be fed and have a roof over their heads. Opal is heartbroken and struggles to forgive him. 

Liverpool, 1946: the blackout blinds may be coming down, but one family is about to face devastating misfortune. Dora Evans is finally marrying the love of her life, and her dreams of opening a dressmaking business look as if they might come true. With twin daughters on the way, Dora has everything she's ever wanted. But then tragedy strikes: one of Dora's babies dies in infancy, and a catastrophic fire changes their lives forever. Can Dora save herself, her marriage and her daughter?

When Sally, Beth, Margaret and Rachel meet at a job interview for the wonderful new store in Oxford Street, they have no idea they will become lifelong friends. When all four girls are lucky enough to be selected as sales staff their exciting new adventure begins. Join them as they overcome heartbreak and grief, find love and happiness and remain united in their friendship, whatever life throws at them.

East-End London, 1858. In London's twisting streets, it's hard to tell friend from foe. And for Katherine Martin, arriving back in London after years away, the city is crueller than she remembers. Her eyes opened to the plight of London's poor, Kate is determined to do what she can to help, even if it means defying her parents. In secret, she opens a soup kitchen. But there is a world of criminals within London's poorest alleys. Catching the notice of Harry Trader and his gang, Kate is out of her depth. Until she begins to discover that her true enemies might not be who she thought.