1850. When Opal Sharp finds herself and her younger siblings suddenly orphaned and destitute, she thinks things can get no worse. But soon three of them - including Opal - are struck down with the illness that took their father from them, and her brother Charlie is forced to make an impossible decision. Unable to afford a doctor, he knows the younger children will not survive. So, unbeknownst to Opal, Charlie takes their younger siblings to the workhouse, where he knows they will at least be fed and have a roof over their heads. Opal is heartbroken and struggles to forgive him. 

 1936. Polly's guardian angel has to work overtime when her large family is forced to move from the countryside they love into central Liverpool. Money is desperately short, and with her mother working and her father sick, Polly is easily led astray by the handsome Sunny Andersen. But soon war looms, and Sunny joins the navy to train as a signaller. After the horrors of the May Blitz, Polly, too, decides she wants to help her country and goes into the WRNs. She hears that an old pal, Tad Donoghue from the Dublin slums, is now in the Royal Air Force.

When the Todds move into a flat on the Scotland Road, they are strangers to city life: their previous home was a canal barge. Harry gets a job as warehouse manager and his wife, Martha, works in a grocer’s shop whilst Seraphina trains as a teacher, Angela works in Bunney’s Department Store and young Evie starts at regular school. Then circumstances change, and Seraphina takes a job in Lyon’s Corner House. Customers vie for her favours, including an old friend, Toby.... 

Liverpool, 1940. When war comes to Britain, Jessica Wilson and her friend Ruby seize the opportunity to leave behind the orphanage they grew up in and start new lives in the NAAFI. With only forged papers as identification, the girls expect to be turned away but are delighted with an offer of work. For the first time in their lives they experience real independence, and it isn't long before they're spending their evenings enjoying the delights of Liverpool.

Paradise Row, London. December 1865. Snow is falling fast, and Sally Suggs is working tirelessly to bring in enough money to keep bread on the table. Her father, a skilled rag-and-bone man, has fallen ill, and now Sally has taken up his trade. But this is a man’s world and competition is fierce, and Sally’s rival, Finn Kelly, always seems to be one step ahead. 

England, 1943: Home is no longer safe for eight-year-old twins Molly and Jacob. Night after night, wailing bombs and screeching planes skim the rooftops overhead. They cradle each other, shivering in terror, not knowing if they'll live to see dawn. Their mother, Martha, has no choice but to evacuate them to the safety of the countryside. At the train station, Martha bites back tears as she says good-bye to her precious children. Knowing she might never see them again, she gives Jacob a letter, pressing the envelope into his hands and telling him to only read it if they are in danger.

Liverpool, 1935. Kathy Kelling is coming home to Daisy Street from her first day at the High School, longing to tell her friend, Jane, all about it. The Kellings' life becomes a struggle when Kathy’s brother, Billy, has a serious accident. He needs constant attention, and Mrs Kelling must take in lodgers so that Kathy’s schooling does not suffer. When war breaks out, Kathy and Jane are forced to grow up fast. Kathy meets the handsome Alec Hewitt, but he is more attracted to blonde, bubbly Jane. But Fate has not yet finished with Kathy Kelling.... 

Emmy Dickens lives with her widowed mother in a neat house in neglected Nightingale Court, but Mrs Dickens has always impressed upon her daughter that her main aim in life must be to escape from the court. Emmy sees that marriage is her best way out, and when Peter Wesley, First Officer aboard a cruise ship, asks her to marry him, she is over the moon. Life goes well for the newlyweds; they set up home and start a family. But when Peter is killed and Emmy is left almost penniless, her problems begin.... 

Liverpool, 1934. Hester Lowe agrees to act as governess to spoiled, self-willed little Lonnie Hetherington-Smith when they leave India to live with Lonnie’s elderly aunt in Shaw Street, Liverpool. Hester speedily realises that her new employer dislikes her niece and means to make life uncomfortable for both of them. Things improve a little when they meet the poor but happy Bailey family, who live in a court off Heyworth Street. Hester likes Dick Bailey very much, but her employer does not permit 'followers', and Lonnie and young Ben Bailey are deadly enemies. 

Liverpool, 1939: 16-year-old Lizzy Atherton is forced to flee her violent stepfather in the middle of the night and finds herself stranded on a station platform completely alone. Desperate to know what has become of her beloved mother, who she had no choice but to leave behind, Lizzy returns the next day only to find her home deserted. Devastated, Lizzy joins forces with her old school friend Dolly and Clara, an escaped evacuee, and vows to find her mother whatever it takes. 

Rose McAllister is waiting for her husband, Steve, to come home. He is a seaman, often drunk and violent. Rose does her best to cope and sees that her daughters, Daisy and Petal, suffer as little as possible. Sensing that war is on the horizon, Steve tries to reform, but on his last night home, he pawns the girls' new dolls to go on a drinking binge. When war is declared, Rose finds a good job but agrees the children must be evacuated. War brings hardship and difficulty for the girls and Rose as they face the destruction of their home and cruelty at the hands of others....  

Amy Logan’s family are poor but proud. They scrape a living by shrimping for the big Liverpool fish market, which Amy hates. It’s only because her beloved - and strict - mother rules her with a rod of iron that she mucks in. But Isobel Logan dies in childbirth, and Amy and her brothers start to run wild. Matters aren’t helped when her father marries Suzie Keagan from down the street. Until now, Suzie has managed to conceal a dislike for housekeeping, and she forces Amy to slave at chores. Desperate to escape, Amy leaves home to take her first job. 

Dana and Caitlin meet on the ferry from Ireland, both in search of new lives in Liverpool, having left their secrets behind in Ireland. But Dana is ambitious, and when the opportunity comes to own their own tearoom she persuades her friend to join her. No one is willing to rent property to a couple of girls, so when Caitlin’s new man-friend says he’ll back them, they are delighted. Soon the tearoom is thriving.

It is a cold December night and Sylvie Dugdale is weeping as she walks by the Mersey. She fails to notice an approaching figure, and jumping to one side to avoid collision, she finds herself struggling in the ice-cold river. Constable Brendan O'Hara, just coming off duty, sees the girl's plight and dives in to rescue her. He is dazzled by her beauty but discovers that Sylvie's husband is in prison, and the closeness that Brendan soon longs for is impossible. But he is able to help her escape from Liverpool....

Liverpool, 1917. When Irish seaman Michael Gallagher docks in Liverpool after years of fighting with the British Navy, he never expects to fall in love. But the moment he glimpses Stella Bennett, all thoughts of returning to his homeland vanish. Determined to be together, the young couple defy Stella’s parents’ wishes. But their plans to marry are soon derailed by the arrival of baby Ginny. Her crop of fiery red hair plants a seed of doubt in her father’s mind, and it’s not long before their world begins to fall apart.