Mary Vale, a grand and imposing Mother and Baby Home, sits on the remote Fylde coast in Lancashire. Its doors are open to unmarried women who come to hide their condition and find sanctuary. Women from all walks of life pass through Mary Vale, from beautiful waitress Emily, whose boyfriend has vanished without trace, to young Isla, cast out by her wealthy family after her first year at university goes horribly wrong. Awaiting them is Nurse Ada and Sister Anne who work tirelessly to aid the mothers and safely deliver the babies. 

Alice Lake has arrived in London from Liverpool to start her training as a District Nurse, but her journey has been far from easy. Her parents think that she should settle down and get married, but she has already had her heart broken once and isn’t about to make the same mistake again. Alice and her best friend, Edith, are based in the East End, but before they’ve even got their smart new uniforms on, war breaks out, and Hitler’s bombs are raining down on London.

It is 1939, and working-class Evie Bishop has received a scholarship to study mathematics at Oxford when tragedy turns her life upside down. Evie must seek a new future for herself and, inspired to contribute to the war effort, joins the Women’s Auxiliary Air Force as an Ops Room plotter. Posted to a fighter station on the Sussex Coast, Evie befriends two other WAAFs. But the German bombers seem to know more than they should about the base’s operations, and soon Evie, May and Jess are caught up in a world more dangerous than they ever imagined. 

Sunderland, 1940, and the women go to the shipyards to do their bit for the war effort. Polly never dreamed she would be able to work in the shipyards like the men in her family but times are tough and her new job ends up giving her more than she ever expected when she meets enigmatic dock diver Tommy Watts. During the day, head welder Rosie teaches her fledgling flock of trainees their new trade, but at night she hides a secret life. And mother hen Gloria signs up to escape her brutal husband, but finds she cannot run....

In February, 1922, at the western-most entrance to Victoria Station in Manchester, a massive plaque was unveiled. Beneath a vast tiled map showing the lines of the Lancashire and Yorkshire Railway network, a series of seven bronze panels recorded the names of the men of the Lancashire and Yorkshire Railway who gave their lives for King and Country in the Great War - a total of 1,460 names. In March, 1940, a group of women of varying ages and backgrounds stands in front of the memorial, ready to do its bit in this new World War.... 

Lillian is distraught - she must register for compulsory war work. Emily is also furious - her dream job as a chef will have to be put on hold, whilst Alice must abandon her plans of college. Staring at an identical letter, Elsie feels a kindling of hope, and down in London Agnes is packing her bags with a smile. Sharing grief and joy, lost dreams and gained opportunities, the five new bomb girls will find friendship and strength that they never before thought possible.

1949. Peggy and Able Ronoscki's seaside cafe in Devon is thriving, and their twins, Fay and Freddie, are growing up fast. To pursue her daughter’s destiny, Fay must train in London and Peggy is faced with a dilemma of moving the family back to London once more. Meanwhile, Peggy’s elder daughter, Janet, has her own troubles. She fears her husband is having an affair and is desperately unhappy. Peggy is torn two ways and can only hope that a reunion with her friends at Christmas can help resolve her problems. 

December 1930. With the Depression biting deeper, it looks like many children in the East End will wake up to nothing on Christmas morning. Widower Robbie Graham earns just enough to put food on the table for his children, Ben and Ruthie. Local cake shop owner Flo Hawkins can't bear the thought of any child having nothing for Christmas. Along with her sister, Honour, she hatches a plan to bring some festive cheer to the community.

Liverpool, 1939. Bella Rogers thought her life was just starting; she can’t wait to get married to her childhood sweetheart, Bobby. But when war is declared and Bobby is called up, his letters stop, leaving Bella heartbroken and alone. Then her family is torn apart by tragedy when her angelic 5-year-old sister dies from a terrible illness. They can barely afford a funeral, but the church is packed with the entire community, devastated for their loss. Grieving for her sister and lost love, Bella finds a job at the Bryant and May factory, making matches.

It is late 1940, and the war feels closer to home than ever for Rose Neville and her staff at the Lyon’s Teashop in Margate. The worry of rationing hangs overhead as the Nippies do their best to provide a happy smile and a hot cup of tea for their customers. When a heavy bombing raid targets the Kent coastline, Lyon’s is badly hit, throwing the future of the cafe into jeopardy. The light in Rose’s life is her dashing fiancé, Capt. Ben Hargreaves, and planning their Christmas Eve wedding. 

London, 1943: Dot Hanson has never forgotten the thrill of seeing the beautiful Christmas displays at Liberty's department store as a young girl. Never in her wildest dreams did she think she would one day work there or that she would fall in love with the store's manager, her childhood sweetheart, Edwin Button. But in spite of the life Dot has built for herself and the tight-knit community around her, she lives in the shadow of a terrible secret. And as the bombs continue to fall across Britain, there is more heartache still to come.

It's 1941 and Britain is at war. For the aristocratic Walsingham family this means their grand home being taken over by the armed forces. But for newcomers Ava, Maudie and Bella, this is a chance for something more. Each is ready to do their part for the war effort and soon become firm friends. But Lord Edward Walsingham seems like he is hiding something. And although he may be clever, he might have met his match in Maudie and the girls....

After the heartbreak of World War Two, newlywed midwife Cathy hoped Liverpool life would offer some joy. But a terrible miscarriage and the escape of her abusive stepfather Jack from prison make happiness hard to find. Meanwhile, Cathy’s beloved granny is ailing. Whilst at the hospital, Cathy sees her midwifery friends, who are planning to open a home for unmarried mothers. After losing a baby of her own, Cathy would love to help, but for now, she must take care of her grandmother.  

August 1941: As war sweeps across Britain and millions of men enlist, women must fight the battle on the home front. Fran always thought she would marry her childhood sweetheart and live in Massingham, the beloved pit village she has always called home. But the opening of a munitions factory in the north-east of England presents a new opportunity. Against her father's wishes and with best friends Sarah and Beth by her side, Fran signs up to join the ranks of women at the factory. It's dangerous work, but the friends discover that their lives are only just beginning. 

The tree that Cotton Cooper was sleeping under as an infant was struck by lightning. As a result, his hair is white (the color of cotton). He is a young man now, but his reflexes are ultrafast. He hears better and sees sharper than the average person. He travels west to visit his brother Paul, who is a captain in the cavalry at Fort Laramie. While visiting, his brother gets orders to take a company of men and help 600 Pawnee Indians move south to the town of Pawnee in Indian Territory.