In 1820, Salem Street is sparkling and new: eight small terraced houses built by a Lancashire mill owner for his best workers. Annie Gibson's family is one of the first to move in - a step up in the world for them. But when her mother dies, Annie's happy childhood ends and she is left to bring up her brother and sister. Red-haired, intelligent and startlingly pretty, Annie soon finds herself banished from home by a jealous stepmother. She finds work in the local doctor's household, where she learns about the fascinating world outside Salem Street.

It is 1937, and Alice, Edith and Marg continue to face hardships every day, growing up on one of the poorest streets in Blackpool. Penniless, their friendship has helped them survive this far, but it'll take more than that to see them through the dark days ahead. Alice is coping with a violent father. Marg is left reeling after a dark secret about her birth comes to light and threatens to destroy the life she knows, and Edith is fighting to protect her alcoholic mother from the shame of their neighbours and keep her brother on the straight and narrow. 

Shocked beyond measure at her wrongful imprisonment, Phoebe Pardoe finds it hard to adjust to the harshness of life in the infamous Handsworth Prison. She struggles to maintain her unconquered spirit, little suspecting that her arrest is the work of her jealous Aunt Annie. Phoebe has a guardian angel in the form of Sir William Dartmouth, who eventually engineers her release. But even so, cruelly disinherited, Phoebe must strive to make a living for herself in a man's world.

1850. When Opal Sharp finds herself and her younger siblings suddenly orphaned and destitute, she thinks things can get no worse. But soon three of them - including Opal - are struck down with the illness that took their father from them, and her brother Charlie is forced to make an impossible decision. Unable to afford a doctor, he knows the younger children will not survive. So, unbeknownst to Opal, Charlie takes their younger siblings to the workhouse, where he knows they will at least be fed and have a roof over their heads. Opal is heartbroken and struggles to forgive him. 

Liverpool 1939: Olivia Campbell appears to have the perfect life. However, behind closed doors she lives in constant fear of her abusive father and has no support from her mother. Longing for love and affection, she begins a relationship with Ted, a young lad who works in her father's factory. But her family disapprove of the relationship and forbid them from seeing each other.

Hull, 1940. Widowed Edie Copeland has just arrived on Exchange Street, heavily pregnant and with heavy suitcase in tow. She left York after tragedy struck to make a fresh start, but she's a stranger to this street, and her new landlord doesn't hesitate to remind her of this, widow or not. Luckily, the neighbours are a little more welcoming and Edie is soon made to feel at home by the Maguires and the Scuttles. As air raids sound and the war feels closer than ever, the community has to stick together. But Edie is hiding something, and she doesn't know how much longer her secret is safe.

Phoebe Parsons is destitute, disgraced and alone. After her mistress tragically dies, Phoebe is forced back onto the poverty-ridden streets of Manchester by her unforgiving new master. Desperately searching for work as a domestic maid, Phoebe soon discovers her reputation is in ruins. Fearing for her future and haunted by the harshness of her abandonment, Phoebe finds herself living with thieves and drunks in the smog and squalor - until she meets Victor Hayes. 

Having suffered much cruelty at the hands of her father, Isabel Kenton is shocked to hear after his death that he was not her real father. Isabel inherits their house while her twin brother, Mark, is left the family steel works. But when World War I breaks out, Mark joins the RAF, and Isabel must take responsibility for the management of the business. Struggling to keep the business alive, she must also discover who she really is.

Winnie Berry had been the landlady for the Battersea Tavern for over 25 years and loved every minute of it. Her husband Brian preferred the quiet of the upstairs, but Winnie liked to be in the thick of it: the atmosphere and the company. While her son has taken after his father in more ways than one, she can't help but love him - David might not be able to hold down a job, but she would do anything to keep him safe. After all, once upon a time she'd made a mistake - something she'd do anything to put right.

East-End London, 1858. In London's twisting streets, it's hard to tell friend from foe. And for Katherine Martin, arriving back in London after years away, the city is crueller than she remembers. Her eyes opened to the plight of London's poor, Kate is determined to do what she can to help, even if it means defying her parents. In secret, she opens a soup kitchen. But there is a world of criminals within London's poorest alleys. Catching the notice of Harry Trader and his gang, Kate is out of her depth. Until she begins to discover that her true enemies might not be who she thought. 

1850: Beatrix Fawcett is just 18 when her father tells her she is to marry a stranger. Hesitant, but with little choice, she agrees to the match - with hope for a good husband in Charles and the surprising delight of a lovely Yorkshire house in which they are to live. As Beatrix sets to making the house a home, she falls in love with it and the countryside nearby. But she does not fall in love with her husband.... It's clear Charles has chosen her simply to meet the requirements of his inheritance and has little interest in his young wife.

Ruby Castleton may only be 25 years old but she already has the weight of the world on her shoulders. Heavily pregnant with her second child, penniless and exhausted, she is moving her family into a new home. The Castletons left their last place when they couldn’t pay the rent, but Ruby’s husband Eddie has promised this will be a fresh start for them all. And Ruby desperately hopes that this time he will keep his word.

In Australia, Simone has been widowed for four years and is ready to make a more interesting life. Her friends are driving her mad introducing her to eligible men; her busy daughters are just the opposite, wanting her available for babysitting. When she is offered a house swap with a couple in the UK she takes it, not without some trepidation. In the UK, Russ has just taken possession of his new house and wants only peace and quiet after a few months of rehab following a serious injury. Can these two help one another avoid meddling friends and relatives and build new lives?

Bristol, 1939. School leaver Maisie Miles suspects her father, a small-time crook, has an ulterior motive for insisting she gets a job at the W. D. & H. O. Wills tobacco factory but keeps it to herself. She's befriended by effervescent Phyllis Mason and kind-hearted Bridget Milligan who take pity on her and take Maisie under their wing. But beneath their happy-go-lucky exteriors, they all harbour dreams and worries about what the future holds. 

Jo Melling has arrived in Birch End from Australia, still grieving her father's recent death. She's not intending to stay long, but after tracking down her distant family, Jo becomes more involved in village life than she could ever have imagined - and suddenly in danger too. Jo also finds herself drawn to Nick, a handsome newcomer to the village. Nick had planned to settle in Birch End and start a business, but as he grows closer to Jo, he realises he may have to choose between his dreams and a chance at love.