Supreme Pharmaceuticals designs and manufactures Enoxadin, a drug that coats the inner walls of arteries and prevents heart attacks and strokes. The medicine, taken by everyone over 20 years old, works wonders for decades until it interacts with a new virus and starts killing the population it's meant to protect. Brent, a scientist from the future, journeys to the past to find four teenagers and warn them of what will befall an unsuspecting populace.
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William, Ellie, and Brent realize their memories have been erased - even though everyone else's is still intact. With Detective Sparks hell-bent on pinning them with Valerie's murder and the threat of a global war in the future, the three friends know their mission is more critical than ever.
Much has happened since Brent, Ellie, William, and Valerie first met an old man from the future. They've saved the world from a terrifying epidemic unwittingly caused by their future selves, only to see the timeline change to an equally devastating outcome. The teens have watched their future selves die and discovered that someone - or something - has tampered with their own memories, erasing years of personal experiences. They're about to find out why.