England faces utter ruin when a viral pandemic erupts in Central London. Within hours of infection, citizens become ravenous creatures seeking to feed upon and infect any living thing they can find. Swiftly they break through Armed Response teams and military units, leaving an ever widening swathe of devastation and chaos in their wake. What started simply with one boy, may now scour the entire globe.
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While plague zombies rage through the streets of London and begin their conquest beyond Britain, Jonathan, Holly, Cassie, and Garth try to stay alive. Vladimir Nesky seeks to complete his mission for Russia by apprehending Patient Zero before MI6's Director Sayers and her special forces team can steal him away to secure a cure for the virus for Britain.